Preparation of <italic style="font-style: italic">in situ</italic> Crosslinked Carboxymethyl Chitosan/Calcium Carbonate Gel Sponge and Its Hemostatic Performance

ZHAO Jing; YANG Xue; SU Xiao-lei; GAO Xin-wei; SU Jing; WANG Hong-bo

doi:10.14028/j.cnki.1003-3726.2023.07.006

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Preparation of in situ Crosslinked Carboxymethyl Chitosan/Calcium Carbonate Gel Sponge and Its Hemostatic Performance

更新时间：2023-05-30

- Preparation of in situ Crosslinked Carboxymethyl Chitosan/Calcium Carbonate Gel Sponge and Its Hemostatic Performance
- Polymer Bulletin Vol. 36, Issue 7, Pages: 844-850(2023)
- 作者机构：
  
  1.江南大学纺织科学与工程学院，无锡　214122
  2.江南大学食品学院，无锡　214122
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2023.07.006
  CLC：
- Published：20 July 2023，
  
  Received：01 November 2022，
  
  Revised：13 December 2022，
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ZHAO Jing, YANG Xue, SU Xiao-lei, GAO Xin-wei, SU Jing, WANG Hong-bo. Preparation of in situ Crosslinked Carboxymethyl Chitosan/Calcium Carbonate Gel Sponge and Its Hemostatic Performance. [J]. Polymer Bulletin 36(7):844-850(2023)
DOI：

ZHAO Jing, YANG Xue, SU Xiao-lei, GAO Xin-wei, SU Jing, WANG Hong-bo. Preparation of in situ Crosslinked Carboxymethyl Chitosan/Calcium Carbonate Gel Sponge and Its Hemostatic Performance. [J]. Polymer Bulletin 36(7):844-850(2023) DOI： 10.14028/j.cnki.1003-3726.2023.07.006.

摘要

以羧甲基壳聚糖(CMCS)、碳酸钙(CaCO

)、葡萄糖酸内酯(GDL)和甘油(GLY)为原料

通过原位相转变制备水凝胶

经冷冻干燥工艺得到止血海绵

用于躯体非压迫性出血。通过扫描电镜、吸水率、孔隙率、溶血实验和全血凝固时间测试分别对海绵的理化性能、血液安全性、止血性能进行研究。当CaCO

与CMCS的质量比为15%时

制得的海绵综合性能最好。该海绵呈疏松多孔片层状

止血时间较医用棉纱布材料缩短了35%

无血液毒性

是一种优良的止血海绵材料。

Abstract

Using carboxymethyl chitosan (CMCS)

calcium carbonate(CaCO

)

glucolactone (GDL)

glycerol (GLY) as raw materials

hydrogels were prepared by

in situ

phase transformation

and hemostatic sponges were obtained by freeze-drying process for body non compressive bleeding. The physical and chemical properties

blood safety and hemostatic properties of sponge were studied by scanning electron microscope analysis

water absorption analysis

porosity analysis

hemolysis test and whole blood coagulation time test. When the mass ratio of CaCO

to CMCS is 15%

the prepared sponge shows the best comprehensive performance. The sponge is porous

and the hemostatic time is 35% shorter than that of medical cotton gauze. It shows no blood toxicity

which is an excellent hemostatic sponge material.

关键词

羧甲基壳聚糖碳酸钙葡萄糖酸内酯海绵止血

Keywords

Carboxymethyl chitosanCalcium carbonateGlucolactoneSpongeHemostasis

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Related Institution

江南大学食品学院

江南大学纺织科学与工程学院

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Public Health, Xiamen University

School of Parmaceutical Sciences, Jiangnan University

School of Biotechnology, Jiangnan University

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Preparation of in situ Crosslinked Carboxymethyl Chitosan/Calcium Carbonate Gel Sponge and Its Hemostatic Performance

DOI：10.14028/j.cnki.1003-3726.2023.07.006

摘要

Abstract

关键词

Keywords

references