聚<italic style="font-style: italic">α</italic>-硫辛酸基黏附水凝胶的研究进展

雒振; 刘文广; 崔春燕

doi:10.14028/j.cnki.1003-3726.2025.25.240

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聚α-硫辛酸基黏附水凝胶的研究进展

高分子水凝胶专题 | 更新时间：2025-12-05

- 聚α-硫辛酸基黏附水凝胶的研究进展
- Progress on Poly(α-lipoic acid)-based Adhesive Hydrogels
- 高分子通报 2025年38卷第12期页码：1789-1806
- 作者机构：
  
  天津大学材料科学与工程学院，贵金属功能材料全国重点实验室，天津 300350
- 作者简介：
  
  E-mail: wgliu@tju.edu.cn
  E-mail: cycui@tju.edu.cn
- 基金信息：
  
  国家自然科学基金(52233008;52473143;52303201)
- DOI：10.14028/j.cnki.1003-3726.2025.25.240
  中图分类号：
- 收稿：2025-08-25，
  
  录用：2025-09-26，
  
  网络出版：2025-11-14，
  
  纸质出版：2025-12-20
- 稿件说明：
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雒振, 刘文广, 崔春燕. 聚α-硫辛酸基黏附水凝胶的研究进展. 高分子通报, 2025, 38(12), 1789–1806.

Luo, Z.; Liu, W. G.; Cui, C. Y. Progress on poly(α-lipoic acid)-based adhesive hydrogels. Polym. Bull. (in Chinese), 2025, 38(12), 1789–1806.
雒振, 刘文广, 崔春燕. 聚α-硫辛酸基黏附水凝胶的研究进展. 高分子通报, 2025, 38(12), 1789–1806. DOI： 10.14028/j.cnki.1003-3726.2025.25.240.

Luo, Z.; Liu, W. G.; Cui, C. Y. Progress on poly(α-lipoic acid)-based adhesive hydrogels. Polym. Bull. (in Chinese), 2025, 38(12), 1789–1806. DOI： 10.14028/j.cnki.1003-3726.2025.25.240.

摘要

生物医用水凝胶黏合剂在组织修复、伤口闭合和药物递送等领域具有重要应用价值。因此，开发兼具高效黏附性、生物可降解性和良好生物安全性的新型水凝胶材料成为研究热点。硫辛酸(lipoic acid

LA)作为一种内源性抗氧化剂，其分子结构中的二硫键赋予其动态可逆的交联能力，同时具备抗炎、抗氧化应激等生物活性。近年来，基于聚硫辛酸的黏附水凝胶因其独特的动态共价化学特性与多重生物功能受到广泛关注。本文系统综述了硫辛酸的分子结构与生物功能、聚硫辛酸的室温稳定机理、水凝胶的构建方法及其在生物医学领域的应用，并对其面临的挑战与未来发展方向进行了展望，旨在为PolyLA基黏附水凝胶未来的理论突破与实践应用提供重要参考。

Abstract

Biomedical hydrogel adhesives have significant application value in fields such as tissue repair

wound closure

and drug delivery. Consequently

the development of novel hydrogel materials that combine high adhesion

biodegradability

and excellent biosafety has become a research focus. Lipoic acid (LA)

an endogenous antioxidant

possesses a disulfide bond in its molecular structure that confers dynamic reversible cross-linking capabilities

along with biological activities such as anti-inflammatory and antioxidant stress properties. In recent years

poly(lipoic acid) (PolyLA)-based adhesive hydrogels have attracted widespread attention owing to their unique dynamic covalent chemistry and multifunctional biological characteristics. This review systematically summarizes the molecular structure and biological functions of LA

room-temperature stabilization mechanisms of PolyLA

methods for constructing PolyLA-based hydrogels

and their applications in the biomedical field. It also discusses the existing challenges and future development directions

aiming to provide important references for the theoretical breakthroughs and practical applications of PolyLA-based adhesive hydrogels in the future.

关键词

Keywords

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DOI：10.14028/j.cnki.1003-3726.2025.25.240

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