聚(3,4-乙烯二氧噻吩):聚(苯乙烯磺酸盐)导电水凝胶神经电子界面

单良杰; 薛羽; 倪志鹏; 刘吉

doi:10.14028/j.cnki.1003-3726.2025.25.250

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聚(3,4-乙烯二氧噻吩):聚(苯乙烯磺酸盐)导电水凝胶神经电子界面

综述 | 更新时间：2026-01-16

- 聚(3,4-乙烯二氧噻吩):聚(苯乙烯磺酸盐)导电水凝胶神经电子界面
- Poly(3, 4-ethylenedioxy-thiophene):Poly(styrenesulfonate) Conductive Hydrogel-based Neural-electronics Interfaces
- 高分子通报 2026年39卷第1期页码：81-96
- 作者机构：
  
  南方科技大学机械与能源工程系　深圳 518055
- 作者简介：
  
  E-mail: liuj9@sustech.edu.cn
- 基金信息：
  
  国家重点研发计划(2024YFA0920100);国家自然科学基金(52373139;U2436202);深圳市基础研究基金(20231116101626002;JCYJ20240813094159001)
- DOI：10.14028/j.cnki.1003-3726.2025.25.250
  中图分类号：
- 收稿：2025-08-31，
  
  录用：2025-09-16，
  
  网络出版：2025-12-16，
  
  纸质出版：2026-01-20
- 稿件说明：
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单良杰, 薛羽, 倪志鹏, 刘吉. 聚(3,4-乙烯二氧噻吩):聚(苯乙烯磺酸盐)导电水凝胶神经电子界面. 高分子通报, 2026, 39(1), 81–96.

Shan, L. J.; Xue, Y.; Ni, Z. P.; Liu, J. Poly(3,4-ethylenedioxy-thiophene):poly(styrenesulfonate) conductive hydrogel-based neural-electronics interfaces. Polym. Bull. (in Chinese), 2026, 39(1), 81–96.
单良杰, 薛羽, 倪志鹏, 刘吉. 聚(3,4-乙烯二氧噻吩):聚(苯乙烯磺酸盐)导电水凝胶神经电子界面. 高分子通报, 2026, 39(1), 81–96. DOI： 10.14028/j.cnki.1003-3726.2025.25.250.

Shan, L. J.; Xue, Y.; Ni, Z. P.; Liu, J. Poly(3,4-ethylenedioxy-thiophene):poly(styrenesulfonate) conductive hydrogel-based neural-electronics interfaces. Polym. Bull. (in Chinese), 2026, 39(1), 81–96. DOI： 10.14028/j.cnki.1003-3726.2025.25.250.

摘要

稳定高效的神经电子界面是实现高精度神经信号采集与功能调控的基础。然而，传统植入式电极与生物组织固有的力学和电学失配会导致电极错位、瘢痕组织形成和信号传输质量差等问题。导电聚合物水凝胶因其具有与组织匹配的模量、可调控的电化学性能和优异的生物相容性，成为理想的神经电子界面材料。本综述总结了近年来导电聚合物(如聚(3

4-乙烯二氧噻吩):聚(苯乙烯磺酸盐)，PEDOT:PSS)水凝胶在神经电子界面领域的研究进展，系统阐述了高性能PEDOT:PSS水凝胶的设计与性能调控策略，以及相应生物电子器件的制造手段，重点介绍了其在神经信号记录与电刺激调控中的应用实例，并深入探讨了当前面临的关键挑战与未来的发展方向。

Abstract

Stable and efficient neural-electronic interfaces are crucial for achieving high-fidelity neural signal acquisition and functional modulation. However

the intrinsic mechanical and electrical mismatches between conventional neural electrodes and biological tissues can lead to electrode dislocation

scar formation

and inferior signal quality. Conductive polymer hydrogels

owing to their tissue-matched modulus

tunable electrical properties

and excellent biocompatibility

have emerged as one of the ideal materials to establish neural-electronic interfaces. This review summarizes recent advances in conductive polymer hydrogels

particularly poly(3

4-ethylenedioxy-thiophene):poly(styrenesulfonate) (PEDOT:PSS)

for neural-electronic interfaces

systematically elucidating the design and performance modulation strategies of high-performance PEDOT:PSS hydrogels

as well as fabrication approaches for the corresponding bioelectronic devices. Special emphasis is placed on their applications in neural signal recording and electrical stimulation modulation

followed by an in-depth discussion of the key challenges and future directions in this field of research.

关键词

Keywords

references

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