可降解聚(<italic style="font-style: italic">L</italic>-丙交酯-<italic style="font-style: italic">co</italic>-<italic style="font-style: italic">ε</italic>-己内酯)的合成及其在外周神经修复中的应用潜力

张丽丹; 胡莎莎; 苏玉贤; 许任科; 张瑗; 张其清

doi:10.14028/j.cnki.1003-3726.2025.25.260

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可降解聚(L-丙交酯-co-ε-己内酯)的合成及其在外周神经修复中的应用潜力

研究论文 | 更新时间：2025-12-05

- 可降解聚(L-丙交酯-co-ε-己内酯)的合成及其在外周神经修复中的应用潜力
- Synthesis of Biodegradable Poly(L-lactide-co-ε-caprolactone) and Its Potential Application in Peripheral Nerve Repair
- 高分子通报 2025年38卷第12期页码：1874-1886
- 作者机构：
  
  1.福建吉特瑞生物科技有限公司，福州 350001
  2.中国医学科学院生物医学工程研究所，天津 300192
- 作者简介：
  
  E-mail: zhangy@gtrbio.cn
  E-mail: zhangqiq@126.com
- 基金信息：
  
  福州市科技计划项目科技创新创业人才培育计划(22023-R-008);“十三五”国家重点研发计划项目(2016YFC1101702)
- DOI：10.14028/j.cnki.1003-3726.2025.25.260
  中图分类号：
- 收稿：2025-09-05，
  
  录用：2025-10-10，
  
  网络出版：2025-11-14，
  
  纸质出版：2025-12-20
- 稿件说明：
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张丽丹, 胡莎莎, 苏玉贤, 许任科, 张瑗, 张其清. 可降解聚(L-丙交酯-co-ε-己内酯)的合成及其在外周神经修复中的应用潜力. 高分子通报, 2025, 38(12), 1874–1886.

Zhang, L. D.; Hu, S. S.; Su, Y. X.; Xu, R. K.; Zhang, Y.; Zhang, Q. Q. Synthesis of biodegradable Poly(L-lactide-co-ε-caprolactone) and its potential application in peripheral nerve repair. Polym. Bull. (in Chinese), 2025, 38(12), 1874–1886.
张丽丹, 胡莎莎, 苏玉贤, 许任科, 张瑗, 张其清. 可降解聚(L-丙交酯-co-ε-己内酯)的合成及其在外周神经修复中的应用潜力. 高分子通报, 2025, 38(12), 1874–1886. DOI： 10.14028/j.cnki.1003-3726.2025.25.260.

Zhang, L. D.; Hu, S. S.; Su, Y. X.; Xu, R. K.; Zhang, Y.; Zhang, Q. Q. Synthesis of biodegradable Poly(L-lactide-co-ε-caprolactone) and its potential application in peripheral nerve repair. Polym. Bull. (in Chinese), 2025, 38(12), 1874–1886. DOI： 10.14028/j.cnki.1003-3726.2025.25.260.

摘要

以

-乳酸为原料合成

-丙交酯(

-LA)中间体，随后将

-LA与

-己内酯(

-CL)共聚，制备了聚(

-丙交酯-

-己内酯) (PLCL)共聚物，并采用压延成型技术将其加工成膜。结果表明，不同投料比的PLCL共聚物具有相似的分子结构。随着

-CL含量的增加，PLCL材料表现出“高分子量+低结晶度”的矛盾特性，其熔融温度和玻璃化转变温度降低，膜的刚性下降而柔韧性提高，体外降解速率加快。这种非常规变化规律表明，通过调节

-丙交酯与

-己内酯的比例，可调控PLCL共聚物的分子量与结晶度，从而实现从“短期快速降解”到“长期稳定支撑” 的全周期性能调控。此外，PLCL膜具备降解周期可调性、柔韧可缝合性以及良好的神经细胞相容性，展现了其在神经修复领域良好的应用前景。

Abstract

Employs

-lactic acid to synthesize the intermediate

-lactide (

-LA)

which was then polymerized with

-caprolactone (

-CL) to form a poly(

-lactide-

-caprolactone) (PLCL) copolymer. The resulting copolymer was processed into a film using calendering technology

and the results indicated that the PLCL copolymers exhibited similar molecular structures across different feed ratios. As the

-CL content increased

the PLCL copolymer exhibited contradictory characteristics of “high molecular weight+low crystallinity” accompanied by decreases in the melting temperature and glass transition temperature. PLCL films exhibit reduced rigidity

enhanced flexibility

and accelerated in vitro degradation rates. This unconventional variation pattern indicates that by adjusting the ratio of

-lactose to

-caprolactone

the molecular weight and crystallinity of PLCL materials can be regulated

enabling full-cycle performance control from “short-term rapid degradation” to “long-term stable support”. Additionally

the adjustable degradation cycle

flexible suturability

and excellent neural cell compatibility of the PLCL membrane demonstrate its promising application prospects in the field of neural repair.

关键词

Keywords

references

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可降解聚(L-丙交酯-co-ε-己内酯)的合成及其在外周神经修复中的应用潜力

Synthesis of Biodegradable Poly(L-lactide-co-ε-caprolactone) and Its Potential Application in Peripheral Nerve Repair

DOI：10.14028/j.cnki.1003-3726.2025.25.260

摘要

Abstract

关键词

Keywords

references