水凝胶在眼部疾病治疗中的研究进展

李嘉怡; 卢越; 陈焕; 庞燕

doi:10.14028/j.cnki.1003-3726.2025.25.269

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水凝胶在眼部疾病治疗中的研究进展

综述 | 更新时间：2026-01-16

- 水凝胶在眼部疾病治疗中的研究进展
- Research Progress of Hydrogel in Eye Diseases Treatment
- 高分子通报 2026年39卷第1期页码：125-152
- 作者机构：
  
  上海市药物靶标发现及递送前沿科学研究基地　创新免疫治疗全国重点实验室　上海交通大学药学院　上海 200240
- 作者简介：
  
  E-mail: chenhuan913@sjtu.edu.cn
  E-mail: yanpang@sjtu.edu.cn
- 基金信息：
  
  国家自然科学基金(52522307;22375127;22305152)
- DOI：10.14028/j.cnki.1003-3726.2025.25.269
  中图分类号：
- 收稿：2025-09-10，
  
  录用：2025-10-19，
  
  网络出版：2025-12-04，
  
  纸质出版：2026-01-20
- 稿件说明：
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李嘉怡, 卢越, 陈焕, 庞燕. 水凝胶在眼部疾病治疗中的研究进展. 高分子通报, 2026, 39(1), 125–152.

Li, J. Y.; Lu, Y.; Chen, H.; Pang, Y. Research progress of hydrogel in eye diseases treatment. Polym. Bull. (in Chinese), 2026, 39(1), 125–152.
李嘉怡, 卢越, 陈焕, 庞燕. 水凝胶在眼部疾病治疗中的研究进展. 高分子通报, 2026, 39(1), 125–152. DOI： 10.14028/j.cnki.1003-3726.2025.25.269.

Li, J. Y.; Lu, Y.; Chen, H.; Pang, Y. Research progress of hydrogel in eye diseases treatment. Polym. Bull. (in Chinese), 2026, 39(1), 125–152. DOI： 10.14028/j.cnki.1003-3726.2025.25.269.

摘要

眼部疾病在全球范围内普遍存在，是威胁视力健康的主要因素。然而，因眼部解剖结构复杂且存在生理屏障，眼部给药时药物生物利用度低，治疗效果不佳。水凝胶作为亲水性高分子材料，具有优异生物相容性、可调控的物理和机械性能，能延长药物滞留并实现缓释，近年来在眼科治疗领域应用潜力巨大。本文系统综述了近年来水凝胶在眼部疾病治疗中的研究进展，着重介绍其多种应用形式，如水凝胶滴眼液、可注射水凝胶、水凝胶隐形眼镜、水凝胶微针及水凝胶植入物，并从交联方式、结构设计与功能化策略等方面总结其制备与优化思路。在此基础上，结合感染与炎症、伤口愈合及组织修复、眼部新生血管、白内障、青光眼及干眼症等常见疾病，系统梳理了水凝胶的作用机制与应用价值。综上，本综述总结了水凝胶在眼科领域的研究热点与最新成果，为未来水凝胶的临床转化与个性化设计提供参考和启示。

Abstract

Eye diseases are prevalent worldwide and have become a major threat to visual health. However

due to the complex anatomical structure and physiological barrier in the eye

resulting in low drug bioavailability and struggle to achieve ideal therapeutic effects. Hydrogels

as a kind of hydrophilic polymer materials

have shown great potential in the field of ophthalmology in recent years due to their excellent biocompatibility

controllable physical and mechanical properties

and the characteristics of prolonging drug retention and slow release. This article systematically reviewed the research progress of hydrogel in the treatment of eye diseases in recent years

focusing on its various application forms

including hydrogel eye drops

injectable hydrogels

hydrogel contact lenses

hydrogel microneedles

and hydrogel implants. The preparation and optimization of hydrogel implants were summarized from the aspects of crosslinking mode

structural design

and functionalization strategies. On this basis

combined with infection and inflammation

wound healing and tissue repair

eye neovascularization

cataract

glaucoma

dry eye and other common diseases

the mechanism of action and application value of hydrogel were systematically combed. In conclusion

this review not only summarized the research hotspots and latest achievements of hydrogels in ophthalmology

but also provided reference and enlightenment for clinical transformation and personalized design of hydrogels in the future.

关键词

Keywords

references

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