基于熔融沉积成型3D打印的聚乳酸/<italic style="font-style: italic">β</italic>-磷酸三钙复合医用多孔骨支架的制备与性能

赵丽萍; 段晓

doi:10.14028/j.cnki.1003-3726.2026.26.009

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基于熔融沉积成型3D打印的聚乳酸/β-磷酸三钙复合医用多孔骨支架的制备与性能

研究论文 | 更新时间：2026-05-29

- 基于熔融沉积成型3D打印的聚乳酸/β-磷酸三钙复合医用多孔骨支架的制备与性能
- Preparation and Properties of Poly(lactic acid)/β-Tricalcium Phosphate Composite Medical Porous Bone Scaffolds Based on Fused Deposition Modeling 3D Printing
- 高分子通报 2026年39卷第6期页码：967-975
- 作者机构：
  
  长治医学院　长治 046000
- 作者简介：
  
  duanxiao0211@czmc.edu.cn
- 基金信息：
  
  国家自然科学基金青年科学基金(82204327)
- DOI：10.14028/j.cnki.1003-3726.2026.26.009
  中图分类号：
- 收稿：2026-02-18，
  
  录用：2026-03-16，
  
  网络首发：2026-05-09，
  
  纸质出版：2026-06-20
- 稿件说明：
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赵丽萍, 段晓. 研究论文基于熔融沉积成型 3D打印的聚乳酸/β-磷酸三钙复合医用多孔骨支架的制备与性能. 高分子通报, 2026, 39(6), 967–975.

Zhao, L. P.; Duan, X. Preparation and properties of poly(lactic acid)/β-tricalcium phosphate composite medical porous bone scaffolds based on fused deposition modeling 3D printing. Polym. Bull. (in Chinese), 2026, 39(6), 967–975.
赵丽萍, 段晓. 研究论文基于熔融沉积成型 3D打印的聚乳酸/β-磷酸三钙复合医用多孔骨支架的制备与性能. 高分子通报, 2026, 39(6), 967–975. DOI： 10.14028/j.cnki.1003-3726.2026.26.009.

Zhao, L. P.; Duan, X. Preparation and properties of poly(lactic acid)/β-tricalcium phosphate composite medical porous bone scaffolds based on fused deposition modeling 3D printing. Polym. Bull. (in Chinese), 2026, 39(6), 967–975. DOI： 10.14028/j.cnki.1003-3726.2026.26.009.

摘要

采用共混造粒—制丝—熔融沉积成型(FDM)3D打印工艺制备聚乳酸/

-磷酸三钙(PLA/

-TCP)复合材料Gyroid多孔骨支架，系统研究

-TCP含量(0 wt%~20 wt%)对力学性能、体外降解与细胞相容性的影响。结果表明，

-TCP能显著提高材料刚度与承载能力：打印拉伸强度由52.3 MPa提升至74.9 MPa(15 wt%)，拉伸模量由2.12 GPa增至3.15 GPa，但断裂伸长率由6.4%降至2.6%，呈现增强伴随一定脆化。压缩曲线表现为“弹性—平台—致密化”三阶段响应，平台承载与吸能能力随

-TCP增加而提高。体外降解中，4周质量损失率由(6.8±0.7)%(PLA)增至(12.7±1.1)%(20 wt%)；同时

-TCP缓冲酸化作用显著，4周浸泡液pH由6.62±0.06 (PLA)提高至7.15±0.06 (20 wt%)。细胞实验显示。复合支架无明显毒性并促进增殖，5天时450 nm 波长光密度值(OD

450

)由0.95(PLA)提高至1.10~1.15(10 wt%~15 wt%)，细胞活死染色以存活细胞为主且铺展良好。综合评价表明，10 wt%~15 wt%

-TCP可实现力学—降解—生物响应的较优平衡，为可降解骨修复支架设计提供参考。

Abstract

Poly(lactic acid)/

-tricalcium phosphate (PLA/

-TCP) composite Gyroid porous bone scaffolds were fabricated

via

a melt compounding–filament extrusion–FDM 3D printing route. The effects of

-TCP content (0 wt%–20 wt%) on mechanical properties

in vitro

degradation behavior

and cytocompatibility were systematically investigated. The results show that

-TCP markedly enhances the stiffness and load-bearing capacity of the composites: the tensile strength of p

rinted specimens increased from 52.3 MPa to 74.9 MPa at 15 wt%

-TCP

and the tensile modulus rose from 2.12 GPa to 3.15 GPa

accompanied by a decrease in elongation at break from 6.4% to 2.6%

indicating strengthening with a certain degree of embrittlement. The compressive response exhibits a typical three-stage behavior—elastic region

plateau region

and densification—with both plateau stress and energy absorption increasing as

-TCP content rises. During in vitro degradation

the mass loss after 4 weeks increased from (6.8±0.7)% for PLA to (12.7±1.1)% for the 20 wt%

-TCP composite; meanwhile

-TCP provided a pronounced buffering effect against acidification

with the immersion medium pH at 4 weeks increasing from 6.62±0.06 (PLA) to 7.15±0.06 (20 wt%

-TCP). Cell studies demonstrate that the composite scaffolds exhibit no evident cytotoxicity and promote cell proliferation: at day 5

the optical density (OD

450

) values increased from 0.95 (PLA) to 1.10–1.15 for the 10 wt%–15 wt%

-TCP groups

and live/dead staining showed predominantly viable cells with good spreading. Overall

-TCP content of 10 wt%–15 wt% provides an optimal balance among mechanical performance

degradation behavior

and biological response

offering a promising strategy for the design of biodegradable bone repair scaffolds.

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Keywords

references

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Preparation and Properties of Poly(lactic acid)/β-Tricalcium Phosphate Composite Medical Porous Bone Scaffolds Based on Fused Deposition Modeling 3D Printing

DOI：10.14028/j.cnki.1003-3726.2026.26.009

摘要

Abstract

关键词

Keywords

references