基于点击化学策略的聚合物分子刷设计、合成与应用研究进展

段承博; 曾尚辉; 王慧; 陈永明

doi:10.14028/j.cnki.1003-3726.2026.26.098

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基于点击化学策略的聚合物分子刷设计、合成与应用研究进展

综述 | 更新时间：2026-07-06

- 基于点击化学策略的聚合物分子刷设计、合成与应用研究进展
- Advances in the Design, Synthesis, and Applications of Molecular Bottlebrushes via Click Chemistry
- 高分子通报 2026年39卷第7期页码：1128-1139
- 作者机构：
  
  河南大学化学与分子科学学院　开封 475001
- 作者简介：
  
  huiwang@henu.edu.cn
  chenyongming@henu.edu.cn
- 基金信息：
  
  国家自然科学基金(52503227)
- DOI：10.14028/j.cnki.1003-3726.2026.26.098
  中图分类号：
- 收稿：2026-02-28，
  
  录用：2026-04-02，
  
  网络首发：2026-05-27，
  
  纸质出版：2026-07-20
- 稿件说明：
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段承博, 曾尚辉, 王慧, 陈永明. 基于点击化学策略的聚合物分子刷设计、合成与应用研究进展. 高分子通报, 2026, 39(7), 1128–1139.

Duan, C. B.; Zeng, S. H.; Wang, H.; Chen, Y. M. Advances in the design, synthesis, and applications of molecular bottlebrushes via click chemistry. Polym. Bull. (in Chinese), 2026, 39(7), 1128–1139.
段承博, 曾尚辉, 王慧, 陈永明. 基于点击化学策略的聚合物分子刷设计、合成与应用研究进展. 高分子通报, 2026, 39(7), 1128–1139. DOI： 10.14028/j.cnki.1003-3726.2026.26.098.

Duan, C. B.; Zeng, S. H.; Wang, H.; Chen, Y. M. Advances in the design, synthesis, and applications of molecular bottlebrushes via click chemistry. Polym. Bull. (in Chinese), 2026, 39(7), 1128–1139. DOI： 10.14028/j.cnki.1003-3726.2026.26.098.

摘要

聚合物分子刷是一种高密度接枝的单分子纳米材料，其具有独特的分子构象、可精准调控的尺寸与拓扑结构，在生物医药、弹性体、表面活性剂等领域受到广泛关注。点击化学作为一种高效、快速和条件温和的偶联反应技术，被用来精准构筑具有复杂拓扑结构的聚合物分子刷。本综述聚焦于点击化学在聚合物分子刷结构设计、精准合成及应用中的研究进展，系统总结了铜催化叠氮–炔环加成和无金属点击反应在调控聚合物分子刷拓扑结构中的应用策略。分析点击反应介导的聚合物分子刷接枝效率和接枝密度的调控机制，阐述聚合物分子刷结构与性能之间的构效关系。在此基础上，总结了聚合物分子刷在生物医药和功能材料等领域的应用进展，并对未来发展方向进行了展望。

Abstract

Molecular bottlebrushes are a class of densely grafted

unimolecular nanomaterials characterized by unique molecular conformations and precisely tunable dimensions and topologies. These materials have garnered significant attention in biomedicine

elastomers

and surfactants. Click chemistry

a highly efficient

rapid

and mild conjugation technique

has emerged as a powerful tool for the precise construction of molecular bottlebrushes with complex architectures. This review focuses on recent advances in the structural design

precision synthesis

and applications of molecular bottlebrushes enabled by click chemistry. This review systematically summarizes the application strategies of copper-catalyzed azide-alkyne cycloaddition and metal-free click reactions for tailoring the topology of molecular bottlebrushes. The regulatory mechanisms governing grafting efficiency and grafting density in click-mediated molecular bottlebrush synthesis were analyzed

and the structure-property relationships of molecular bottlebrushes were elucidated. Furthermore

the progress of molecular bottlebrush applications in biomedical and functional materials is reviewed

and future directions in this rapidly evolving field are discussed.

关键词

Keywords

references

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