聚乙二醇拓扑结构对自身免疫原性的影响

王雯靖; 李明

doi:10.14028/j.cnki.1003-3726.2026.26.118

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聚乙二醇拓扑结构对自身免疫原性的影响

综述 | 更新时间：2026-07-06

- 聚乙二醇拓扑结构对自身免疫原性的影响
- Effect of Poly(ethylene glycol) Topology on Self-immunogenicity
- 高分子通报 2026年39卷第7期页码：1140-1147
- 作者机构：
  
  河南大学化学与分子科学学院　开封 475004
- 作者简介：
  
  lming@henu.edu.cn
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2026.26.118
  中图分类号：
- 收稿：2026-03-02，
  
  录用：2026-04-10，
  
  网络首发：2026-05-25，
  
  纸质出版：2026-07-20
- 稿件说明：
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王雯靖, 李明. 聚乙二醇拓扑结构对自身免疫原性的影响. 高分子通报, 2026, 39(7), 1140–1147.

Wang, W. J.; Li, M. Effect of poly(ethylene glycol) topology on self-immunogenicity. Polym. Bull. (in Chinese), 2026, 39(7), 1140–1147.
王雯靖, 李明. 聚乙二醇拓扑结构对自身免疫原性的影响. 高分子通报, 2026, 39(7), 1140–1147. DOI： 10.14028/j.cnki.1003-3726.2026.26.118.

Wang, W. J.; Li, M. Effect of poly(ethylene glycol) topology on self-immunogenicity. Polym. Bull. (in Chinese), 2026, 39(7), 1140–1147. DOI： 10.14028/j.cnki.1003-3726.2026.26.118.

摘要

聚乙二醇(PEG)凭借其优良的生物相容性，在医药领域，特别是在新兴纳米药物领域有着广泛应用，但其本身的免疫原性引发的抗PEG抗体及加速血液清除(ABC)效应等问题限制其临床价值。本综述重点分析对传统PEG进行线性结构改造以及枝状、刷状、星型等不同拓扑结构改造策略，通过破坏抗体识别所需的连续乙二醇表位、优化表面构象与密度，可显著降低抗PEG抗体结合及补体激活，规避ABC效应与补体激活相关的假性过敏(CARPA)。改造后的PEG衍生物在延长纳米载体循环时间、增强肿瘤靶向富集、提升重复给药疗效等方面表现优异。

Abstract

Poly(ethylene glycol) (PEG) is extensively utilized in the biomedical field

particularly in emerging nanomedicines

owing to its excellent biocompatibility. However

its clinical value is constrained by issues such as immunogenicity-induced production of anti-PEG antibodies and the accelerated blood clearance (ABC) phenomenon. This review focuses on strategies for modifying conventional PEG through linear structural alterations and the development of different topological architectures

including branched

brush-like

and star-shaped structures. By disrupting the continuous ethylene glycol epitopes required for antibody recognition and optimizing the surface conformation and density

these modifications significantly reduce anti-PEG antibody binding and complement activation

thereby circumventing the ABC effect and complement activation-related pseudoallergy (CARPA). The resulting PEG derivatives exhibited superior performance in prolonging the circulation time of nanocarriers

enhancing tumor-targeted accumulation

and improving therapeutic efficacy upon repeated administration.

关键词

Keywords

references

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