With the development of science and technology in genomics

biochemistry

molecular biology and peptide synthesis

protein drugs are becoming very important ones and widely used in clinical. However

the low stability

fast clearance and immunogenicity of protein drugs become the major hindrances in their efficient clinical applications. Thus

the polymer-protein conjugation becomes a more and more vital method to improve the efficiency of protein drug in clinic. In this paper

we discussed the development of the application of poly(ethylene glycol)(PEG) in the polymer-protein conjugation technology in recent years

and the advantages and limitations of this technology. And we also discussed the recent advance in other new polymeric materials and methods for the polymer-protein conjugation.