Chitosan (CS) is a polycationic biopolymer

one of the most abundant natural polysaccharides in nature. With numerous desirable properties such as good biocompatibility

biodegradability

pH response

non-toxicity and no stimulation to human tissues

chitosan has emerged as a promising drug delivery. The PMA30 was synthesized by free radical polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and methacrylic acid (MA) with the MPC monomer molar percentage in the feed of 30%. The CS-PMA30 polyelectrolyte hydrogel was prepared through electrostatic interaction between chitosan polycation and PMA30 polyanions. In vitro drug release of coomassie brilliant blue G-250 from the CS-PMA30 hydrogel was determined by dialysis method. The results suggest that the CS-PMA30 hydrogel with phosphorylcholine groups is a good system for drug delivery due to pH-sensitive and biocompatibility may have potential applications in the fields of drug delivery

and tissue engineering.