Xiao-xia FAN, Xue-ying ZHANG, Run SUN, Yong-gang YAN. The Preparation and Characterization of Amino Acids Polymer with in vitro and in vivo Bioactivity[J]. Polymer Bulletin, 2019,32(3):35-42.
Xiao-xia FAN, Xue-ying ZHANG, Run SUN, Yong-gang YAN. The Preparation and Characterization of Amino Acids Polymer with in vitro and in vivo Bioactivity[J]. Polymer Bulletin, 2019,32(3):35-42. DOI: 10.14028/j.cnki.1003-3726.2019.03.004.
A polymer mainly prepared with 6-aminohexanoic acid and another assistant five kinds of amino acids were synthesized in this study for evaluating the physicochemical characteristic
in vitro
and
in vivo
bioactivity as bone repair materials. The transforms infrared (FT-IR)、X-ray diffraction analysis (XRD)、differential scanning calorimetry(DSC) and thermal gravity analysis(TG) were investigated and characterized; The scanning electron microscopy (SEM) was tested for evaluating the
in vitro
bioactivity after soaking the polymer into simulated body fluid (SBF) with five days; The implantation of polymer into muscles and femur condyle of rabbits was assessed for evaluating the
in vivo
bioactivity of the polymer. The results showed that the polymer possessed amide band and was semi-crystallization structure
further the melting temperature and crystallization temperature was 205.9℃ and 159.5℃
respectively; The polymer could induce the form of apatite in the surface of polymer
showing good bioactivity; The implantation of polymer into muscles and femur condyle of rabbits results stated that the polymer had no visible inflammation and had contacted directly between implants and tissue without newly formed fibrous connective tissue. The fluorescence results showed that the polymer may possessed ectopic osteogenesis and have exactly great osteoconductivity
in vivo.
关键词
六元氨基酸聚合物体外活性体内活性
Keywords
Hexa-amino acidsPolymerIn vitro bioactivityIn vivo bioactivity