The antibacterial micro-nano fiber membrane loaded with zinc oxide (ZnO)/polylactic acid (PLA)/ polycaprolactone (PCL) was prepared by electrostatic spinning technology. And the surface morphology
elementary composition and chemical structure of the composite membrane were characterized by scanning electronic microscope (SEM)
X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR)
respectively. The antibacterial performance of the composite membrane was evaluated by the antibacterial experiment. The drug release behavior of the composite membrane
in vitro
was measured by ultraviolet spectrophotometer. The results showed that ZnO and LAH were successfully mixed into the composite micro-nano fibers by physical blending; Concerning to the antibacterial properties
ZnO/PLA/PCL micro-nano fiber composite membranes exhibited better antibacterial efficiency compared to the PLA/PCL micro-nano fiber composite membranes. When the ZnO content was 10% (wt)
the composite fiber membrane had the best antibacterial performance. The drug release performance results showed that the ZnO/PLA/PCL micro-nano fiber composite membrane had good drug release performance.