Injectable hydrogel has attracted much attention in the field of biomedicine due to its unique properties. Chitosan is the only cationic polysaccharide found in nature

which has the advantages of abundant content

low price

good biocompatibility and biodegradability

and is often used to prepare injectable hydrogel. In recent years

with the further development of research

injectable chitosan hydrogels with excellent properties were springing up by using various chemical or physical modification and functionalization methods

introducing various biological functional molecules or using various cross-linking methods. Their application scope has been expanding and they have played an increasingly important role in practical applications. In this article

the common preparation methods of injectable chitosan hydrogel with chemical crosslinking and physical crosslinking were introduced. The applications in drug carrier

gene vector

cell scaffold and wound repair were reviewed

and the existing problems and development trends were analyzed and prospected

which provided guidance and reference for the further development of injectable chitosan hydrogels.