Using carboxymethyl chitosan (CMCS)

calcium carbonate(CaCO

3

)

glucolactone (GDL)

glycerol (GLY) as raw materials

hydrogels were prepared by

in situ

phase transformation

and hemostatic sponges were obtained by freeze-drying process for body non compressive bleeding. The physical and chemical properties

blood safety and hemostatic properties of sponge were studied by scanning electron microscope analysis

water absorption analysis

porosity analysis

hemolysis test and whole blood coagulation time test. When the mass ratio of CaCO

3

to CMCS is 15%

the prepared sponge shows the best comprehensive performance. The sponge is porous

and the hemostatic time is 35% shorter than that of medical cotton gauze. It shows no blood toxicity

which is an excellent hemostatic sponge material.