In this review the relation between biocompatibility of biomaterials and conformation of proteins was expounded.The elaboration includes four propositions as follows:1.The natural conformation of protein is the basis of its biofunctions

2.The sysnergistic effect of peptide chain-lataral group is the driving source for both the foundation of natural conformation and the accomplishment of biofunction of proteins

3.Protein adsorption of biomaterials

4.Relation between biocompatibility of biomaterials and conformation of proteins. It is concluded that one of the best way improving biocompatibility of biomaterials is to maintain the natural conformation of proteins and cells contacted

in that both "Maintaining Normal Conformation" hypothesis and "Chemical Amplification" principle will play a positive role.