Since bioerodible polymers may lead targetable and prolonged drug releasing behavior

especially for the drugs which are highly unstable and have short half-life

in vivo

bioderodible polymers were widely investigated recently.One of the important directions of designing controlled drug delivery system with bioerodible polymer matrix is using mathematical approaches to simulate or predict the drug releasing behavior. Due to numerous mass transport phenomena and chemical reactions would influence the drug releasing

it would not be reasonable to take all these factors into account.Generally

one mathematical model would only consider several crucial parameters and assume that drug releasing would follow some kinetics.There are mainly two categories of mathematical models:Empirical Models which assume drug release follows zero order process kinetics and Mechanistic Models which consider the influence of chemical and physical phenomena. The aim of this article is to give an introduction of these models and the relating researching progress.