Jin HUANG, Shi-long WANG, Xiao-yu SUN, Wen-zhe LI, Si-de YAO. Advance in the Study of Chitosan and its Derivatives as Non-Viral Vectors[J]. Polymer Bulletin, 2006,19(1):65-69.
Jin HUANG, Shi-long WANG, Xiao-yu SUN, Wen-zhe LI, Si-de YAO. Advance in the Study of Chitosan and its Derivatives as Non-Viral Vectors[J]. Polymer Bulletin, 2006,19(1):65-69. DOI: 10.14028/j.cnki.1003-3726.2006.01.010.
Recently chitosan is focused in the research of gene delivery system for it is already known as a biocompatible
biodegradable and non-toxic polysaccharide.This article is to summarize the recent development of chitosan and its derivatives as non-viral vectors for gene transfection.And the influential factors of the transfection efficiency are also discussed such as molecular mass of chitosan
size of chitosan nanoparticle and depolymerization of chitosan.