Hui YAN, Fei QIU, Yong DIAO. The Latest Progress in Polymeric Prodrug of 5-Fluorouracil and Targeting Drug Delivery[J]. Polymer Bulletin, 2011,24(6):22-29.
Hui YAN, Fei QIU, Yong DIAO. The Latest Progress in Polymeric Prodrug of 5-Fluorouracil and Targeting Drug Delivery[J]. Polymer Bulletin, 2011,24(6):22-29. DOI: 10.14028/j.cnki.1003-3726.2011.06.011.
5-fluorouracil is one of the most widely used cytotoxic antitumor agents.It has been used in the carcinomas of colon
breast
gastrointestinal tract and liver.But its activity is also accompanied by strong side effects that had greatly limited its clinical applications.Polymeric prodrugs of5-fluorouracil can reduce its toxicity
increase duration of antitumor activity and additionally
an affinity for tumor cells.In this review the research on polymeric prodrug of 5-fluorouracil and their targeting antitumor activities were reported.
关键词
5-氟尿嘧啶高分子前药靶向给药
Keywords
5-FluorouracilPolymerProdrugTargeting drug delivery