Dan-dan MA, Ke HU, Xiao-e MA, Nai-zhen ZHOU, Ning GU, Tian-zhu ZHANG. A Review of Smart Hydrogel for 3D Cell Culture[J]. Polymer Bulletin, 2015,28(12):47-53.
Dan-dan MA, Ke HU, Xiao-e MA, Nai-zhen ZHOU, Ning GU, Tian-zhu ZHANG. A Review of Smart Hydrogel for 3D Cell Culture[J]. Polymer Bulletin, 2015,28(12):47-53. DOI: 10.14028/j.cnki.1003-3726.2015.12.006.
Compared with the traditional two-dimensional(2D) cell culture
in vitro three-dimensional(3D) cell culture is much closer to the growth microenvironment of cells. The smart hydrogel has good biocompatibility. The special structure and property of smart hydrogel can mimic the extracellular matrix(ECM) and help us achieve the goal of 3D cells culture. Furthermore
the smart hydrogel also has sensitive response to the external environment stimulus
which can change the cells’ microenvironment and enable us to study cell behaviors in 3D model. In this review
we discuss the smart hydrogel and 3D cell culture
review the different types of smart responsive hydrogel and introduce the influence of 3D scaffold on cell behaviors.