Thermosensitive hydrogels can respond to the change of temperature and attract much attention in practical applications. Among them

poly (

N

-isopropylacrylamide) (PNIPAM) is one of the most widely studied and applied thermosensitive hydrogels because of its good thermosensitivity

simple preparation and easy modification. In recent years

with the further development of research

especially the progress of chemical modification and functionalization technology

a variety of novel PNIPAM thermosensitive hydrogels with excellent response performance have emerged. The depth and breadth of their applications have been expanded and updated

which are more close to the actual needs. So PNIPAM thermosensitive hydrogels have broad prospects in the fields of biomedicine

chemical industry and so on. In this article

the principle of thermosensitivity and main preparation methods of PNIPAM hydrogels are introduced. The application situation and development trend of PNIPAM hydrogels in drug release

cell scaffold

sensor analysis and material separation are discussed. The existing problems and development prospects of PNIPAM hydrogels are analyzed and prospected. This review could provide a reference for the further development of PNIPAM thermosensitive hydrogels.