The treatment of malignant tumor has always attracted much attention in clinical practice. Due to the invasiveness and recalcitrance of tumor cells

conventional treatment schedules generally produce serious toxic side effects. Compared with systemic chemotherapy

the administration of local medical-loaded gels significantly reduces systemic toxicity and enables sustained drug delivery at the tumor site. In addition

stimulation-responsive hydrogels with physical doping or chemical modification can respond to changes in environmental conditions (

e.g.

temperature

pH

light)

achieve gelation

in situ

and controlled drug release

which greatly enhances clinical compliance and efficiency of drug delivery. In this review

we classified and discussed the design strategies of stimulation-responsive hydrogels and summarized the research progress of such hydrogels for tumor treatment in recent years and their drug delivery schemes. Finally

the possible development direction of this field is proposed according to some existing problems.