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1.广州中医药大学中药学院,广州 510006
2.广东云浮中医药职业学院,云浮市中药(南药)资源开发利用与中药材GAP研究重点实验室,云浮 527400
*林雅立,E-mail: lybeishan@163.com;何建峰,E-mail: syrinx@gzucm.edu.cn
*林雅立,E-mail: lybeishan@163.com;何建峰,E-mail: syrinx@gzucm.edu.cn
纸质出版日期:2024-10-20,
网络出版日期:2024-07-15,
收稿日期:2024-03-25,
录用日期:2024-05-27
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林雅立, 张敏慧, 邱欣琪, 刘育, 徐文洁, 邬泉周, 何建峰. 表面硼酸亲和柚皮苷分子印迹微球的制备及其特异分离性能研究. 高分子通报, 2024, 37(10), 1470–1481
Lin, Y. L.; Zhang, M. H.; Qiu, X. Q.; Liu, Y. Xu, W. J.; Wu, Q. Z. He, J. F. Study on preparation and specific separation properties of boronate affinity-based surface molecularly imprinted microspheres with naringin as template. Polym. Bull. (in Chinese), 2024, 37(10), 1470–1481
林雅立, 张敏慧, 邱欣琪, 刘育, 徐文洁, 邬泉周, 何建峰. 表面硼酸亲和柚皮苷分子印迹微球的制备及其特异分离性能研究. 高分子通报, 2024, 37(10), 1470–1481 DOI: 10.14028/j.cnki.1003-3726.2024.24.085.
Lin, Y. L.; Zhang, M. H.; Qiu, X. Q.; Liu, Y. Xu, W. J.; Wu, Q. Z. He, J. F. Study on preparation and specific separation properties of boronate affinity-based surface molecularly imprinted microspheres with naringin as template. Polym. Bull. (in Chinese), 2024, 37(10), 1470–1481 DOI: 10.14028/j.cnki.1003-3726.2024.24.085.
以4-乙烯苯硼酸(VPBA)、甲基丙烯酸甲酯(MMA)为功能单体,乙二醇二甲基丙烯酸酯(EDMA)为交联剂,通过悬浮聚合法制得硼酸功能化聚合微球;并以此微球为载体,利用硼酸亲和作用,将柚皮苷模板分子锚定在微球表面,再通过盐酸多巴胺(DA)与聚乙烯亚胺(PEI)的氧化自聚共沉积作用在微球表面进行印迹涂覆,最后酸洗去除柚皮苷模板,制备得到表面硼酸亲和柚皮苷分子印迹微球(SMIMs)。利用扫描电子显微镜、激光共聚焦显微镜、水接触角实验、氮气吸附-脱吸附以及红外光谱对SMIMs进行表征,结果表明SMIMs表面形成了亲水性印迹薄膜。吸附实验结果表明,SMIMs在水相条件下具有较高的吸附容量、优异的特异选择性和较快的吸附动力学速率。固相萃取实验表明以SMIMs作为固相萃取柱吸附材料,能够有效地分离化橘红粗提物中的柚皮苷组分,其洗脱回收率为50.52%。
Boric acid functionalized polymer microspheres were prepared
via
suspension polymerization by using methacrylate (MMA) and 4-vinylphenylboronic acid (VPBA) as functional monomers
and ethyleneglycol dimethacrylate (EDMA) as crosslinkers
respectively. Naringin template was covalently a
nchored onto the surface of the microspheres by boronate affinity
and then a thin coating layer of dopamine and polyethyleneimine was formed onto the microspheres surface
via
oxidative self-copolymerization. After removal of the template with an acidic solution
the naringin surface molecularly imprinted microspheres (SMIMs) based on boronate affinity were obtained. The resulting materials were characterized by scanning electron microscopy
laser confocal microscopy
water contact angle experiment
nitrogen adsorption/desorption and infrared spectroscopy. The results show that the hydrophilic imprinted film has been successfully formed on the surface of boric acid functionalized polymer microspheres (BPMs). The adsorption experiments indicate that the SMIMs possess high adsorption capacity
excellent specific selectivity and fast adsorption kinetic rate toward template under water phase conditions. In addition
the extraction experiments reveal that the SMIMs as the adsorbed materials of solid phase extraction (SPE) can effectively separate naringin from
Exocarpium Citri Grandis
extract
and the total recovery of elution solution can reach 50.52%.
柚皮苷硼酸亲和表面印迹微球多巴胺共涂覆萃取分离
NaringinBoronate affinitySurface imprinted microspheresDopamine co-coatingExtraction separation
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Yan, Y.; Zhou, H.; Wu, C. H.; Feng, X. Y.; Han, C. G.; Chen, H.; Liu, Y.; Li, Y. F.Ultrasound-assisted aqueous two-phase extraction of synephrine, naringin, and neohesperidin from Citrus aurantium L. fruitlets. Prep. Biochem. Biotechnol., 2021, 51(8), 780–791.
刘磊磊, 李立, 瞿利民, 肖卓炳. 正交实验优化柚皮中柚皮苷的超声辅助双水相提取工艺. 食品工业科技, 2018, 39(21), 159–163.
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Feng, S. T.; Zhang, A.; Wu, F. S.; Luo, X. G.; Zhang, J.In-situ growth of boronic acid-decorated metal-organic framework on Fe3O4 nanospheres for specific enrichment of cis-diol containing nucleosides. Anal. Chim. Acta, 2022, 1206, 339772.
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