最新刊期
卷 34 ， 期 12 ， 2021
- 摘要：Due to its excellent biocompatibility and unique structure of hydrophobic core and hydrophilic shell, natural polymer-based nano-micelles have been widely researched in the biomedical field as carriers for lipid-soluble drug or nanoprobes loading to increase their solubility and stability. Polysaccharides have the advantages of excellent water solubility, wide sources and easy chemical modification, and the amphiphilic polysaccharide derivatives after hydrophobic modification can self-assemble into natural polymer micelle nanoparticles in aqueous solution. The preparation of amphiphilic polysaccharides is a key step for the design and formation of polysaccharide micelles. Therefore, in this paper, the commonly used methods for the hydrophobic modification of polysaccharides, including side chain esterification, side chain ring-opening polymerization, terminal reductive amination, and hydrophobic drug grafting were reviewed in detail. And, further functionalization and application of amphiphilic polysaccharide micelles as drug carriers were introduced.关键词：Polysaccharides;Polymeric micelles;Hydrophobic modification;Drug carrier
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发布时间：2022-08-30 - 摘要：Shape memory hydrogels (SMHs) are functional polymer materials with the advantages of shape memory effect, high water content, and good biocompatibility. Their porous structures and high strength provide excellent tissuelike microenvironments for cell adhesion, growth and migration. Particularly, the shape memory abilities under external stimuli endow them attractive applications in artificial intelligence and medicines. The progress in synthetic methods, principle of shape memory as well as their applications including 3D printing, sensors, soft robots, tissue engineering, and information transmission are reviewed in this paper. Based on structures and properties, challenges and research trends faced by SMHs are discussed.关键词：Shape memory;Application;Hydrogel
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发布时间：2022-08-30 - 摘要：At present, antitumor drugs in clinic are mostly small molecules, which have some disadvantages such as poor water solubility, uncontrolled drug release behavior and high toxicity. Due to amphiphilic polymers can self-assemble to form nano-micelles with "core-shell" structure and tumor tissues and their intracellular environment are weakly acidic as compared to the neutral normal tissues, the acid-responsive amphiphilic polymers as antitumor drug carriers have drawn a lot of attentions in the recent decade. This article emphatically introduced the structure characteristics of acid-responsive amphiphilic polymers as drug carriers, and the functional characteristics were expounded from improving the stability of micelle in blood circulation, enhancing cell uptake ability and controlling drug release. In addition, the future research prospect of acid-responsive amphiphilic polymers as drug carriers was also put forward.关键词：Acid-responsive;Amphiphilic;Polymer;Drug carrier
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发布时间：2022-08-30 - 摘要：In this paper, the cyclodextrin supramolecular systems and polypseudorotaxane with different structures are classified according to their shapes. The preparation methods of different shapes of polypseudorotaxane are introduced in detail, and the principle of selection of host and guest and the end-capping technology are systematically summarized and analyzed. On this basis, the development and applications of cyclodextrin-based rotanes in new materials, biomedicine and molecular devices are summarized, and put forward suggestions and prospects for the development and existing problems of cyclodextrin supramolecular system.关键词：Supramolecular;Cyclodextrin;Polyrotaxane;Self-assembly
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发布时间：2022-08-30 - 摘要：The effects of different antioxidants on the molecular structure, anti-aging effect and mechanical properties of carbon black filled SIBR were studied by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), Mooney viscosity and tensile test. The results showed that the aging process of SIBR was degradation reaction in the early stage and crosslinking reaction in the later. The results of oxidation induction temperature of SIBR raw rubber were consistent with that of infrared spectrum and the raw rubber with antioxidant A had the longest oxidation induction period, which indicated that antioxidant A had the best anti-aging effect. The tensile mechanical properties of SIBR vulcanizate filled with carbon black showed that the anti-aging effect of antioxidant was improved with the increase of carbon black content.关键词：SIBR;Antioxidant;Thermo-oxidative aging;DSC;FT-IR
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发布时间：2022-08-30 - 摘要：Bovine serum albumin hydrogel has excellent biocompatibility and biodegradability, and is widely used in the field of tissue engineering. So far, injectable bovine serum albumin hydrogel has been successfully prepared, but its mechanical properties still need to be improved. This paper used a simple method to improve the mechanical properties of the injectable albumin hydrogel. Urea was used as a denaturant and glutathione was used as a reducing agent to prepare an albumin gel network with the synergistic effect of hydrogen bonds and disulfide bonds, and the cationic polypeptide ε- polylysine was physically mixed in the system after the protein was completely denatured. ε-polylysine was adsorbed into the chains of bovine serum albumin molecular by electrostatic interaction and gradually formed hydrogen bonds with bovine serum albumin and urea to strengthen the bovine serum albumin gel network while the injectability of the hydrogel was retained. The results showed that the hydrogel with ε-polylysine could increase the maximum compressive stress from 105kPa to 315kPa, and the storage modulus from about 8kPa to 17kPa. The improvement of mechanical properties expands the application of albumin hydrogel in the field of tissue engineering.关键词：Bovine serum albumin;ε-Polylysine;Injectable hydrogel;Ionic bonding;Hydrogen bonding
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发布时间：2022-08-30 - 摘要：Due to the unique physical structure and chemical properties, amphiphilic polymers have an important role in biomedicine, especially in the field of drug release. In this study, a new block copolymer poly (aspartate-tyrosine-alanine) was synthesized by ring-opening polymerization, and its structure was characterized by FT-IR and 1H-NMR. The model drug doxorubicin was loaded by self-assembly based on the block polymer, and the drug nanocarriers with pH response were constructed. The morphology, particle size and distribution of drug-loaded nanoparticles were characterized by scanning electron microscopy (SEM) and dynamic light scattering (DLS), respectively. The results showed that the particle size of drug-loaded nanoparticles in solution is less than 220nm and had obvious pH response. The release effect of drug-loaded nanoparticles in acidic conditions is obviously higher than that in neutral and alkaline conditions. In addition, in vitro cytotoxicity experiments showed that the polyamino acid material was not toxic to L-929 cells.关键词：Amino acid;Block copolymer;Nano-carrier;Doxorubicin;Drug release
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发布时间：2022-08-30 - 摘要：O/W type Pickering high internal emulsion was prepared by using ball milling lignin and Tween80 as composite stabilizer and cyclohexane as oil phase. The effects of volume fraction of internal phase, amount of ball milling lignin and emulsifier dosage on the size and distribution of emulsion droplets were investigated.The results showed that compared with the ball milling lignin as a single stabilizer, the composite stabilizer was easier to prepare high internal phase emulsion, and the emulsion formed was more stable. The average particle size of the high phase emulsion droplet was about 100μm. When the volume fraction of internal phase increased, the emulsion fluidity increased, the emulsion droplet decreased and the average particle size decreased significantly. When the amount of ball milling lignin increased, the viscosity of emulsion increased, and the average particle size of emulsion droplet increased and the obvious deformation occurred. Increasing the dosage of Tween80 could increased the number of emulsion and decrease the average diameter of emulsion, and the average particle size of emulsion droplets decreased. By combining Tween80 with ball-milled lignin as a composite stabilizer, the stability of the high internal phase emulsion can be greatly improved, and Tween80 and ball-milled lignin have a synergistic effect.关键词：Ball milled lignin;Tween80;Pickering high internal phase emulsion;Synergistic effect
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发布时间：2022-08-30 - 摘要：In this paper, related research was carried out on the problems of low effective content of solvent-based EVA pour point depressant, high pour point, and difficulty in injection. The ethylene-vinyl acetate copolymer (EVA) was synthesized through high-pressure polymerization and emulsified under the action of emulsifier. An emulsion type crude oil pour point depressant with high effective content, no delamination after long-term storage, and excellent pour point depressant effect was developed. The effects of the addition of vinyl acetate, polymerization temperature, pressure, emulsifier type, emulsification temperature and stirring rate on the EVA emulsion were studied. The optimal process conditions were: the reaction pressure 20MPa; the reaction temperature 80℃; the ratio of vinyl acetate to solvent was 3∶ 4; the composite emulsifier was AEO-3∶sodium oleate=1∶3; the emulsification temperature 90℃; the stirring revolutions 1500r/min. The emulsion pour point depressant has the advantages of high stability and good dispersibility. When applied to Niger crude oil, the pour point reduction range can reach 12℃.关键词：Ethylene-vinyl acetate copolymer;High content;Polymerization;Emulsion;Pour point depressant
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发布时间：2022-08-30 - 摘要：In order to promote the internationalization of undergraduate education and improve students' international competitiveness and cross-cultural communication ability, the undergraduate school of Zhejiang University set up English- Taught Courses Led by Overseas Teachers in 2015. Taking this opportunity, the Department of Polymer Science and Engineering of Zhejiang University invited Prof. Andreas Greiner, Prof. Hans-Werner Schmidt and Prof. Seema Agarwal from the University of Bayreuth in Germany to offer an English-Taught Course "Progress in Polymer Science and Engineering" on the basis of three core professional courses "Polymer Chemistry" , "Polymer Physics" and "Polymer Materials" . The motivation of this course is to enable students to get familiar with the courses from another perspective, strengthen their English communication ability, and improve the internationalization of undergraduate education in our department. This paper summarized the teaching content, teaching form, teaching effect and students' experience of this course. Combined with the current trend of internationalization of undergraduate education in universities, we want to share the teaching experience of English-Taught Courses.关键词：English-taught courses;Polymer science and engineering;Teaching reformation;Internationalization of education;Overseas Teachers
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发布时间：2022-08-30 - 摘要：The entanglement is characteristic of polymer chains, resulting in particular crystal structure and motion mode of polymer, as well as high internal viscosity of polymer melt and favorable strength of polymer material. In the teaching course of polymer physics, the relevant knowledge points involved in entanglement were sorted out and integrated, and the relationship between entanglement and crystallization, rubber plateau, mechanical properties and viscosity was introduced and summarized in detail. This will help students better master the thinking logic of the polymer system and integrate the important knowledge points of polymer physics. Students strengthen their understanding and memory, and deepen the understanding of the structural characteristics, motion mode and the relationship between structure and performance of polymer.关键词：Polymer physics;Teaching;Entanglement
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发布时间：2022-08-30 - 摘要：Polymer Physics course is not friendly for a beginner due to its abstract concepts. During the epidemic period, students usually are not able to be self-disciplined to study at home. This dilemma challenges teaching. This paper therefore explores a new teaching form by employing the flip class with an addition of a project study in groups and an oral defense online. The study theme is "knowledge on polymer physics in Taobao products" . Considering the current epidemics, the topic study focuses on applications of concepts in polymer physics to epidemic prevention and treatments. By curiosity-driven interests and excitement, teaching and industrial applications are easy to be combined into one. Students are encouraged to apply knowledge to prevent epidemic diseases, and facilitated to establish social responsibilities as a talent in polymer areas.关键词：Online teaching;Flip class;Polymer physics;Learning interests
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发布时间：2022-08-30 - 摘要：Under the background of the national promotion of engineering education, colleges and universities are facing opportunities and challenges of talent training, which call for optimizing professional talent training objectives, constructing curriculum system of scientific and rigorous,promoting teaching reform of classroom, and improving the quality of education and teaching. Based on the educational concept of OBE, this paper explored effective classroom teaching methods, thinking about the integration of the OBE concept base on top-level design of talent training program, Seeking the fulcrum of the teaching system base on goal of talent training, exploring effective teaching mode based on optimizing teaching content and methods. Follow the systemic principles, this paper proposed the model of "ladder growth model" combination competition and course, integrates extracurricular competition into the process classroom teaching, trains students' innovative thinking and engineering ability, and achieving the goal of cultivating engineering talents for economic construction and social development.关键词：OBE;Combination of competition and course;Education mode;Ladder growth model
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发布时间：2022-08-30 - 摘要："Polymer-based composites" is an important basic course for the students majoring in polymer materials and engineering in many domestic universities. The traditional teaching method focused mainly on imparting basic concepts, theories, and methods, but ignored the training of the problem-solving ability and innovation thinking. To change this teaching situation, Case-based teaching method was introduced in the teaching process of "Polymer-based composites", combining with the characteristics of the composite materials. The students were encouraged to analyze and solve problems independently. The teaching reform practice shows that Case-based teaching method is helpful in cultivating students' innovative mind and improving their abilities to solve engineering practice problems.关键词：Polymer-based composites;Case-based teaching method;Innovative mind;Teaching reform
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发布时间：2022-08-30 - 摘要：The teaching content of "polymer materials" is closely related to practical application, which contains more ideological and political elements. Guided by the concept of ideological and political education, the course has been properly designed. Combined with the microstructure and performance characteristics of different kinds of polymer materials, such as general plastics, engineering plastics, rubber, fiber and so on. By using figurative teaching methods such as metaphor and association, the professional knowledge is connected with the ideas of "unity, courage, determination, national selfconfidence and green development". Moral education is permeated into every unit of curriculum learning. At the same time, it helps students to master professional knowledge and realize the goal of strengthening ideals and beliefs, cultivating the spirit of hard struggle, strengthening ideological and moral cultivation and patriotism.关键词：Polymer materials;Ideological and political courses;Moral education;Teaching design
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发布时间：2022-08-30
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