Conjugated polymers have a strong ability to capture light

which can be used to amplify the fluorescence signal and greatly improve the detection sensitivity.Conjugated polymer-based biosensing systems have important applications in understanding the information transfer in biological systems

especially in the early diagnosis of disease.Because of good chemical and thermal stabilities

high fluorescence quantum yield and easy modification

in recent years

water-soluble polyfluorene derivatives have been widely used in the field of biosensing.In this review

the design

synthesis and properties of water-soluble polyfluorene derivatives and their applications in sensitive biological detection are introduced

and finally futuret rends in this area are discussed .