最新刊期
卷 36 ， 期 5 ， 2023
- 摘要：The incidence and mortality of cancer kept rising for years. Cancer has become one of the most serious diseases threatening human health in the world. Due to the difficulty of precisely targeting the tumor cells, diagnosis and treatment of cancer is always a problem. Molecularly imprinted polymer (MIP) is a kind of synthetic receptor with tailored recognizable sites on its molecule. It provides a way to selectively recognize tumor cells. Presently, molecular imprinted polymers are widely used in the preparation of anticancer drug carrier materials. It has become a specific targeting tool for the diagnosis and treatment of cancer. The application of molecular imprinted polymer in the diagnosis and treatment of malignant tumors (including using anticancer drugs as the templates, and templates based on a protein molecule modeling) was reviewed in this paper. In addition, molecular imprinted polymers also inhibit breast cancer growth by blocking the human epidermal growth factor receptor-2 (HER2) transducing pathway. The current challenges and future prospects of molecular imprinted polymer application in cancer therapy are also discussed.关键词：Malignant tumor;Molecularly imprinted polymer;Tumor markers;Anti-cancer drugs;Diagnosis and treatment integration
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发布时间：2023-03-06 - 摘要：The treatment of malignant tumor has always attracted much attention in clinical practice. Due to the invasiveness and recalcitrance of tumor cells, conventional treatment schedules generally produce serious toxic side effects. Compared with systemic chemotherapy, the administration of local medical-loaded gels significantly reduces systemic toxicity and enables sustained drug delivery at the tumor site. In addition, stimulation-responsive hydrogels with physical doping or chemical modification can respond to changes in environmental conditions (e.g., temperature, pH, light), achieve gelation in situ, and controlled drug release, which greatly enhances clinical compliance and efficiency of drug delivery. In this review, we classified and discussed the design strategies of stimulation-responsive hydrogels and summarized the research progress of such hydrogels for tumor treatment in recent years and their drug delivery schemes. Finally, the possible development direction of this field is proposed according to some existing problems.关键词：Stimulus-responsive hydrogels;Stimulus responsive;Hydrogels;Drug controlled release;Drug delivery systems;Antitumor
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发布时间：2023-03-06 - 摘要：In recent years, antibacterial modification of polymer materials by grafting has attracted extensive attention because it can endow polymer materials with excellent antibacterial properties without changing original characteristics of polymer. And antibacterial polymer materials have been widely used in our lives. In this paper, some antibacterial groups (ones with N-halogenated amine structures, positively charged antibacterial active ones, etc.) are reviewed, which are commonly used in antibacterial modification of polymer materials by grafting at home and abroad. Additionally, the antibacterial effect and mechanism of the above groups in polymer materials are introduced, and the future development trend of antibacterial polymer materials by grafting modification is prospected.关键词：Polymer materials;Antibacterial modification;Grafting;Antibacterial effect
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发布时间：2023-03-06 - 摘要：Rubber is subjected to certain loads during use, which will lead to fatigue failure. The failure is caused by crack propagation and may eventually lead to complete fracture of the material. This paper summarizes the general research methods of rubber fatigue resistance and the fatigue failure mechanism of rubber. Moreover, the influence of mechanical load history, fillers, dynamic bonds, environment and other factors on rubber fatigue performance were reviewed. Finally, the challenges and development of rubber fatigue performance research in future were envisaged.关键词：Rubber;Crack growth;Fatigue resistance;Research method;Influence factor
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发布时间：2023-03-06 - 摘要：Aggregation-induced emission (AIE) materials have been extensively applied in fluorescence detection, bioimaging and organic light-emitting devices owing to their unique luminescence properties. In this paper, the applications of AIE materials in the monitoring of polymerization processes (including bulk polymerization, solution polymerization, emulsion polymerization and suspension polymerization) have been reviewed. Meanwhile, researches of fluorescence detection of the glass transition temperature, viscosity, molecular weight and phase separation of polymers based on AIE materials have been summarized. Finally, the application of AIE-based materials in polymer science is prospected.关键词：Aggregation-induced emission materials;Monitoring of polymerization;Performance Detection;Fluorescence response
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发布时间：2023-03-06 - 摘要：In this paper, a thermo-sensitive Pickering emulsion was prepared using self-assembled colloidal particles loaded-lipase as emulsifiers and n-hexadecane as oil phase. Through changing the temperature, the lipase at the interface of Pickering emulsion droplets is easy to be recycled. Firstly, lipase and negatively charged sodium hyaluronic acid (HA) were added into positively charged chitosan (CS) solution. The self-assembled lipase@chitosan/sodium hyaluronate colloidal particles (CRL@CS/HA CPs) are formed because of the electrostatic interactions between CS, HA and CRL. The lipase was loaded in the colloidal particles and its stability was improved. To construct a thermo-sensitive Pickering emulsion, the prepared CRL@CS/HA CPs was used as stabilizer, and n-hexadecane as oil phase. By changing the temperature, the oil phase undergoes solidification and dissolution, realizing the separation of oil and water and thus the recycling of CRL@CS/HA CPs.关键词：Self-assembled colloid;Lipase;Pickering emulsion;Thermo-sensitive emulsion;Biocatalysis
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发布时间：2023-03-06 - 摘要：Phloridzin has a wide range of application prospects in the development of new drugs and natural health foods. Due to the complexity and low solubility of its ingredients, the research on phloridzin is extremely challenging. The molecular recognition ability of hydroxypropyl-β-cyclodextrin to phloridzin guest was studied by nuclear magnetic resonance, ultraviolet-visible spectroscopy, fluorescence emission spectroscopy and other detection methods. The results show that hydroxypropyl-β-cyclodextrin enhances the solubility of phloridzin in water, forming a molar ratio of 1∶1 host-guest complex in water with a complexation constant of 2.35×102 L·mol-1. The addition of hydroxypropyl-β-cyclodextrin caused fluorescence quenching of phloridzin, and the competition between metal ions and phloridzin for binding to hydroxypropyl-β-cyclodextrin will cause the fluorescence enhancement of the inclusion complex. The bonding constant between Fe3+ and hydroxypropyl-β-cyclodextrin reaches 1.52×104 L·mol-1. It can provide theoretical research for the drug research of phloridzin.关键词：Hydroxypropyl-β-cyclodextrin;Supramolecular;Phloridzin;Molecular recognition;Metal ions
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发布时间：2023-03-06 - 摘要：Poly(1,4-cyclohexanedimethanol terephthalate) modified by synergistic copolymerization of bio-based isosorbide (ISB) and isophthalic acid (IPA), which is called PICTA in this study, was prepared by direct esterification process. The effect of ISB unit content on the properties of PICTA copolyester was studied when the IPA unit content was 15 mol%, in order to develop an amorphous high heat-resistant copolyester. The molecular structure, thermal properties, crystalline properties and thermal degradation properties of PICTA copolyester were investigated using nuclear magnetic resonance hydrogen spectroscopy (1H-NMR), differential scanning calorimeter (DSC), X-ray diffractometer (XRD) and thermogravimetric analyzer (TGA). The results showed that the glass transition temperature of PICTA copolyester increases linearly by about 0.8 ℃ for every 1 mol% increase in the unit content of ISB. When the proportion of ISB copolymerization increased to 25.4 mol%, the PICTA copolyester samples annealed at 180 ℃ for 10 h tended to be in an amorphous state, which indicated that the introduction of ISB copolymerization units could significantly inhibit the crystallization capability of PICTA copolyesters. In addition, the results of TGA study showed that the PICTA copolyester had good thermal stability and the initial thermal decomposition temperature was higher than 405 ℃, but the presence of ISB copolymerization units did not change the thermal decomposition mechanism of the copolyester.关键词：Isosorbide;Poly(1,4-cyclohexanedimethanol terephthalate);Amorphous;Heat resistant copolyester
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发布时间：2023-03-06 - 摘要：Starfish have strong regenerative abilities and are rich in collagen (SSC) in their body walls. Using methacrylated hyaluronic acid (HAMA) and methacrylated collagen (SSCMA) as raw materials, combined with marine source Chlorella growth factor (CGF), the composite hydrogel was prepared by ultraviolet cross-linking method, and the mechanical properties, swelling properties, degradation properties and microstructure of the composite hydrogels were analyzed, and the toxicity and proliferation effects of the composite hydrogels on cells were also verified. The SSCMA/HAMA/CGF composite hydrogels were observed by scanning electron micros-copy to have an obvious pore-like structure, and the mechanical properties of the hydrogels were also improved with the increase of the HAMA ratio. When the addition amount of HAMA is 60%, the swelling rate of the composite hydrogel within 24 h is the largest, which can reach about 5 times of its own weight. After 30 days of degradation, SSCMA/HAMA/CGF-75 undergoes the greatest amount of degradation. SSCMA/HAMA/CGF composite hydrogel has no toxic and side effects on mouse epidermal fibroblasts (L929), shows good cytocompatibility, and has obvious proliferation effect on mouse embryonic fibroblasts (NIH-3T3), among which SSCMA/HAMA/CGF-60 had the highest cell proliferation rate, reaching 129.70%.关键词：Starfish shell collagen;Hyaluronic acid;Photocrosslinking;Hydrogel;Cytotoxicity
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发布时间：2023-03-06 - 摘要：The setting of tire curing process depends on the curing parameters of each component, and ultimately determines the curing efficiency, energy consumption and product quality of tires. The accuracy of curing parameters is crucial.The vulcanization crosslinking reaction of rubber products conforms to the first-order kinetic equation. The vulcanization reaction of silica filled rubber is not only the sulfur accelerator crosslinking reaction, but also the physical effect of polar agglomeration of silica. The vulcanization behavior cannot be accurately characterized by directly using the data measured by the rheometer.Based on this, the vulcanization behavior of silica filled master batch (without sulfur) was studied in this paper, indicating that the agglomeration of silica interfered with the torque increase during vulcanization test. Finally, the vulcanization curves of silica filled final rubber and master rubber were "subtracted" according to the "time torque" data, and the curves that can more accurately characterize the vulcanization dynamic behavior were redrawn to better guide the setting of tire vulcanization process.关键词：Silica filled rubber;Rheological dynamics;Arrhenius equation;Silica agglomeration
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发布时间：2023-03-06 - 摘要：In the face of the new scientific and technological revolution and industrial transformation, it is urgent to cultivate engineering talents with innovation and entrepreneurship ability, global competency and the ability to solve complex engineering problems. In order to build a first-class polymer materials and engineering major and cultivate first-class undergraduate talents, the college of polymer science and engineering of Sichuan University adheres to the major construction principles of world-class, Chinese characteristics and Sichuan University style, and preliminarily constructs the "six whole" talent training mode of the whole elements, the whole curriculum, the whole teachers, the whole process, the whole direction and the whole way with "strengthening morality education" as the foundation, the curriculum ideological and political construction as the starting point, the optimization of curriculum system and improvement of teaching system as the support, the facilitation of teaching and research work, integration of production and education and international cooperation as means. This research has certain reference significance and promotion value for the training of first-class talents in universities.关键词："Double first class" construction;Polymer materials and engineering major;"Six whole";Talent training mode
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发布时间：2023-03-06
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